An International Journal for Oncology Research.  

 


April 2010
Volume 12, Number 4
Cover Illustration:
The cover represents an artistic depiction of the results by Lawrenson et.al., wherein a three-dimensional model of stromal-epithelial interactions was used to demonstrate that senescent fibroblasts promote neoplastic transformation of partially transformed ovarian epithelial cells.

TABLE OF CONTENTS

Research Article

The extracellular matrix glycoprotein elastin mircofibril interface located protein 2: A dual role in the tumor microenvironment.
Maurizio Mongiat, Stefano Marastoni, Giovanni Ligresti, Erica Lorenzon, Monica Schiappacassi, Roberto Perris, Sergio Frustaci and Alfonso Colombatti
Abstract   Full Article

A novel molecular diagnostic of glioblastomas: Detection of an extracellular fragment of PTPmu
Susan M Burden-Gulley, Theresa J. Gates, Adam M. Burgoyne, Jennifer L. Cutter, David Lodowski, Shenandoah Robinson, Andrew E. Sloan, Robert H. Miller, James P. Basilion and Susann M Brady-Kalnay
Abstract   Full Article

Senescent fibroblasts promote neoplastic transformation of ovarian epithelial cells in a three-dimensional model of early stage ovarian cancer
Kate Lawrenson, Barbara Grun, Elizabeth Benjamin, Ian J Jacobs, Dimitra Dafou and Simon A Gayther
Abstract   Full Article

Small molecule inhibitors of Wnt/â-catenin/lef-1 signaling Induces apoptosis in chronic lymphocytic leukemia cells in vitro and in vivo.
Rajesh Kumar Gandhirajan, Peter Anton Staib, Katharina Minke, Iris Gehrke, Günther Plickert, Axel Axel Schlösser, Esther Schmitt, Michael Hallek and Karl-Anton Kreuzer
Abstract   Full Article

Pigment epithelium-derived factor stimulates tumor macrophage recruitment and is down-regulated by the prostate tumor microenvironment
Sofia Halin, Stina Häggström Rudolfsson, Jennifer A Doll, Susan E Crawford, Pernilla Wikström and Anders Bergh
Abstract   Full Article

The eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP downregulation and DR5 induction independent of inhibition of cap-dependent protein translation
Songqing Fan, Yikun Li, Ping Yue, Fadlo R Khuri and Shi-Yong Sun
Abstract   Full Article

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