An International Journal for Oncology Research.  

 


February 2010
Volume 12, Number 2
Cover Illustration:
The cover represents an artistic depiction of the results presented by Clauss et.al., wherein FISH analysis was used to demonstrate genomic gain at the PI3 locus in ovarian cancer.

TABLE OF CONTENTS

Research Article

A mutant of hepatitis B virus X protein (HBx¦¤127) promotes cell growth via a positive feedback loop involving 5-lipoxygenase and fatty acid synthase
Qi Wang, Weiying Zhang, Qiang Liu, Xuan Zhang, Na Lv, Lihong Ye and Xiaodong Zhang
Abstract   Full Article

GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche.
Yusuke Shiozawa, Elisabeth A. Pedersen, Lalit R. Patel, Anne M. Ziegler, Aaron M. Havens, Younghun Jung, Jingcheng Wang, Stephanie Zalucha, Robert D. Loberg, Kenneth J. Pienta and Russell Taichman
Abstract   Full Article

c-Met overexpression contributes to the acquired apoptotic resistance of nonadherent ovarian cancer cells through a cross talk mediated by phosphatidylinositol 3-kinase and extracellular signal–regulated kinase 1/2
Maggie K. S. Tang, Hong Y. Zhou, Judy W. P. Yam and Alice S Wong
Abstract   Full Article

In vivo imaging of xenograft tumors using an epidermal growth factor receptor-specific Affibody molecule labeled with a near-infrared fluorophore
Haibiao Gong, Joy Kovar, Garrick Little, Huaxian Chen and D. Michael Olive
Abstract   Full Article

Translocation of p53 to mitochondria is regulated by its lipid binding property to anionic phospholipids and it participates in cell death control
Ching-Hao Li, Yu-Wen Cheng, Po-Ling Liao and Jaw-Jou Kang
Abstract   Full Article

Overexpression of Elafin in ovarian carcinoma is driven by genomic gains and activation of the NF-κB pathway and is associated with poor overall survival
Adam Clauss, Vivian Ng, Joyce Liu, Huiying Piao, Moises Russo, Natalie Vena, Qing Sheng, Michelle S Hirsch, Tomas Bonome, Ursula Matulonis, Azra H Ligon, Michael J Birrer and Ronny Drapkin
Abstract   Full Article

Constitutive expression of the á4 integrin correlates with tumorigenicity and lymph node metastasis of the B16 murine melanoma.
Robert B Rebhun, Hua Cheng, Jeffrey E Gershenwald, Dominic Fan, Isaiah J Fidler and Robert R Langley
Abstract   Full Article

Three-dimensional (3D) nuclear telomere architecture is associated with differential time to progression and overall survival in glioblastoma patients
Macoura Gajdi, Fortin David, Tsanaclis Ana-Maria, Garini Yuval, Nir Katzir, Yifat Wienburg, Ju Yan, Ludger Klewes, Thomas Klonisch, Regen Drouin and Sabine Mai
Abstract   Full Article

Bone morphogenetic protein 7 Is expressed in prostate cancer metastases and its effects on prostate tumor cells depends on cell phenotype and the tumor microenvironment
Colm Morrissey, Lisha G Brown, Tiffany E Pitts, Robert L Vessella and Eva Corey
Abstract   Full Article

Phase I study of combination treatment with PTK 787/ZK 222584 and cetuximab for patients with advanced solid tumors; safety, pharmacokinetics, pharmacodynamics analysis
Marlies HG Langenberg, Petronella O Witteveen, Nienke AG Lankheet, Jeanine ML Roodhart, Hilde Rosing, Ingeborg JGM van den Heuvel, Jos H Beijnen and Emile E Voest
Abstract   Full Article

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